Mohun T J, Brennan S, Dathan N, Fairman S, Gurdon J B
Nature. 1984;311(5988):716-21. doi: 10.1038/311716a0.
Muscle actin genes are the earliest yet described to show cell type-specific activation in amphibian embryos. Gene-specific probes show that alpha-skeletal and alpha-cardiac actin genes start to be transcribed simultaneously at the end of gastrulation, but only in those regions of the mesoderm that subsequently form embryonic muscle. Their expression provides a molecular marker for early cell determination.
肌肉肌动蛋白基因是迄今所描述的最早在两栖动物胚胎中表现出细胞类型特异性激活的基因。基因特异性探针显示，α-骨骼肌动蛋白基因和α-心肌动蛋白基因在原肠胚形成末期开始同时转录，但仅在中胚层中随后形成胚胎肌肉的那些区域。它们的表达为早期细胞分化提供了分子标记。
