Lewis R A, Schoenwald R D, Eller M G, Barfknecht C F, Phelps C D
Arch Ophthalmol. 1984 Dec;102(12):1821-4. doi: 10.1001/archopht.1984.01040031479027.
An analogue of ethoxzolamide, 6-hydroxyethoxzolamide, was synthesized to enhance corneal permeability yet retain carbonic anhydrase inhibitory activity for use in lowering intraocular pressure. In a 1% suspension, the analogue caused a small but statistically significant unilateral reduction of IOP when applied to one eye of normal rabbits. When formulated in a gel vehicle, 6-hydroxyethoxzolamide caused a more prolonged and larger reduction in IOP in normal and ocular hypertensive rabbits compared with its effect in suspension or with the parent compound.
合成了乙氧唑胺的类似物6-羟基乙氧唑胺，以提高角膜通透性，同时保留碳酸酐酶抑制活性，用于降低眼压。在1%的混悬液中，将该类似物应用于正常兔的一只眼睛时，可引起眼压出现轻微但具有统计学意义的单侧降低。当制成凝胶制剂时，与混悬液或母体化合物相比，6-羟基乙氧唑胺在正常兔和高眼压兔中引起的眼压降低作用更持久、幅度更大。
