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神经降压素B是大鼠脑中一种主要的类铃蟾肽：神经降压素B和神经降压素C在大鼠脑、垂体和脊髓中的区域分布。

Neuromedin B is a major bombesin-like peptide in rat brain: regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord.

作者信息

Minamino N, Kangawa K, Matsuo H

出版信息

Biochem Biophys Res Commun. 1984 Nov 14;124(3):925-32. doi: 10.1016/0006-291x(84)91046-5.

DOI:10.1016/0006-291x(84)91046-5
PMID:6548910
Abstract

Neuromedin B and neuromedin C are the novel mammalian bombesin-like peptides isolated from porcine spinal cord. We have developed highly specific and sensitive radioimmunoassays for neuromedin B and neuromedin C, and determined their regional distribution in rat central nervous system. Prior to measurements of the tissue contents, immunoreactive neuromedin B and C were characterized by gel-filtration and high performance liquid chromatography. Neuromedin B and C immunoreactivities have similar regional distribution in rat brain, but the content of immunoreactive neuromedin B is 2-6 times higher than that of immunoreactive neuromedin C in every region. These results indicate that neuromedin B is a major endogenous bombesin-like peptide in rat brain and has specific functions of physiological importance.

摘要

神经降压素B和神经降压素C是从猪脊髓中分离出的新型哺乳动物铃蟾肽样肽。我们已开发出针对神经降压素B和神经降压素C的高特异性和高灵敏度放射免疫分析法，并确定了它们在大鼠中枢神经系统中的区域分布。在测量组织含量之前，通过凝胶过滤和高效液相色谱对免疫反应性神经降压素B和C进行了表征。神经降压素B和C的免疫反应性在大鼠脑中具有相似的区域分布，但在每个区域中，免疫反应性神经降压素B的含量比免疫反应性神经降压素C高2至6倍。这些结果表明，神经降压素B是大鼠脑中主要的内源性铃蟾肽样肽，具有重要的生理功能。

相似文献

1
Neuromedin B is a major bombesin-like peptide in rat brain: regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord.神经降压素B是大鼠脑中一种主要的类铃蟾肽：神经降压素B和神经降压素C在大鼠脑、垂体和脊髓中的区域分布。
Biochem Biophys Res Commun. 1984 Nov 14;124(3):925-32. doi: 10.1016/0006-291x(84)91046-5.
2
Neuromedin B and neuromedin Ca. Two mammalian bombesin-like peptides identified in porcine spinal cord and brain.
Ann N Y Acad Sci. 1988;547:373-90. doi: 10.1111/j.1749-6632.1988.tb23904.x.
3
Immunoreactive neuromedin B and neuromedin C: distribution and molecular heterogeneity in rat and human tissue extracts.免疫反应性神经介素B和神经介素C：大鼠和人体组织提取物中的分布及分子异质性
Am J Gastroenterol. 1987 Oct;82(10):1035-41.
4
Regional distribution of neuromedin K and neuromedin L in rat brain and spinal cord.神经介素K和神经介素L在大鼠脑和脊髓中的区域分布。
Biochem Biophys Res Commun. 1984 Nov 14;124(3):731-8. doi: 10.1016/0006-291x(84)91019-2.
5
Neuromedin B-32 and B-30: two "big" neuromedin B identified in porcine brain and spinal cord.
Biochem Biophys Res Commun. 1985 Jul 31;130(2):685-91. doi: 10.1016/0006-291x(85)90471-1.
6
Distribution and localization of neuromedin B-like immunoreactivity in pig, cat and rat spinal cord.神经降压素B样免疫反应性在猪、猫和大鼠脊髓中的分布与定位
Neuroscience. 1985 Aug;15(4):1217-26. doi: 10.1016/0306-4522(85)90264-7.
7
Distribution and chromatographic characterization of neuromedin B-like immunoreactivity in the human spinal cord.神经降压素B样免疫反应性在人脊髓中的分布及色谱特征
Brain Res. 1985 Sep 2;342(1):183-6. doi: 10.1016/0006-8993(85)91372-1.
8
Assessment of neuromedin B polyclonal antibodies as molecular probes in neural tissue.神经介素B多克隆抗体作为神经组织分子探针的评估
J Neurosci Methods. 1988 Mar;23(2):161-72. doi: 10.1016/0165-0270(88)90188-4.
9
Neuromedin B-like peptides in rat brain: biochemical characterization, mechanism of release and localization in synaptosomes.
Peptides. 1986 Sep-Oct;7(5):815-20. doi: 10.1016/0196-9781(86)90100-2.
10
Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord.神经介素B：在猪脊髓中发现的一种新型铃蟾肽样肽。
Biochem Biophys Res Commun. 1983 Jul 29;114(2):541-8. doi: 10.1016/0006-291x(83)90814-8.

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International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
国际药理学联合会。第六十八部分。哺乳动物蛙皮素受体：命名、分布、药理学、信号传导以及在正常和疾病状态下的功能。
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Br J Cancer. 1999 Jan;79(2):214-20. doi: 10.1038/sj.bjc.6690036.
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Proc Natl Acad Sci U S A. 1985 Nov;82(22):7616-20. doi: 10.1073/pnas.82.22.7616.
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Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9819-22. doi: 10.1073/pnas.89.20.9819.
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J Clin Invest. 1992 Oct;90(4):1436-42. doi: 10.1172/JCI116010.