Petitjean P, Mouchet P, Pellissier G, Manier M, Feuerstein C, Demenge P
Eur J Pharmacol. 1984 Oct 15;105(3-4):355-9. doi: 10.1016/0014-2999(84)90632-0.
Intrathecal (i.t.) administration of apomorphine at the upper thoracic level lowered blood pressure and heart rate in awake rats. This decrease was dose-dependent and competitively antagonized by haloperidol (i.v. and i.t.) or domperidone (i.t.) but not by domperidone (i.v.). Furthermore, these effects of apomorphine were not affected by alpha- and beta-blocking drugs (i.t.). The results suggest a spinal site, at least in part, for the cardiovascular effect of apomorphine.
在清醒大鼠的上胸段进行鞘内注射阿扑吗啡可降低血压和心率。这种降低呈剂量依赖性，且可被氟哌啶醇（静脉注射和鞘内注射）或多潘立酮（鞘内注射）竞争性拮抗，但不能被多潘立酮（静脉注射）拮抗。此外，阿扑吗啡的这些作用不受α和β受体阻断药物（鞘内注射）的影响。结果表明，阿扑吗啡的心血管效应至少部分是通过脊髓部位起作用的。
