Abergel R P, Meeker C A, Lam T S, Dwyer R M, Lesavoy M A, Uitto J
J Am Acad Dermatol. 1984 Dec;11(6):1142-50. doi: 10.1016/s0190-9622(84)80194-2.
Various laser modalities are currently in extensive use in dermatology and plastic surgery, particularly for treatment of vascular and pigmented lesions. A relatively new area of laser utilization involves the possible biologic effects of the lasers. In this overview, we are summarizing our recent studies, which indicate that lasers at specific wavelengths and energy densities modulate the connective tissue metabolism by skin fibroblasts both in vitro and in vivo. Specifically, the neodymium-yttrium-aluminum-garnet (Nd: YAG) laser was shown to selectively suppress collagen production both in fibroblast cultures and in normal skin in vivo, thus suggesting that this laser modality may be useful for the treatment of fibrotic conditions such as keloids and hypertrophic scars. Furthermore, two low-energy lasers, helium-neon (He-Ne) and gallium-arsenide (Ga-As), were shown to stimulate collagen production in human skin fibroblast cultures, suggesting that these lasers could be used for enhancement of wound healing processes. These experimental approaches illustrate the future possibilities for applying lasers for the modulation of various biologic functions of cells in tissues and attest to the potential role of lasers in the treatment of cutaneous disorders.
目前，各种激光疗法在皮肤科和整形外科中广泛应用，尤其是用于治疗血管性和色素性病变。激光应用的一个相对较新的领域涉及激光可能产生的生物学效应。在本综述中，我们总结了我们最近的研究，这些研究表明特定波长和能量密度的激光在体外和体内均可调节皮肤成纤维细胞的结缔组织代谢。具体而言，钕钇铝石榴石（Nd:YAG）激光在成纤维细胞培养物和体内正常皮肤中均显示出选择性抑制胶原蛋白生成，因此表明这种激光疗法可能对治疗瘢痕疙瘩和增生性瘢痕等纤维化疾病有用。此外，两种低能量激光，氦氖（He-Ne）和砷化镓（Ga-As），在人皮肤成纤维细胞培养物中显示出刺激胶原蛋白生成，这表明这些激光可用于促进伤口愈合过程。这些实验方法说明了应用激光调节组织中细胞的各种生物学功能的未来可能性，并证明了激光在治疗皮肤疾病中的潜在作用。
