Fondacaro J D, Han J, Yoon M S
Am Heart J. 1978 Jul;96(1):81-6. doi: 10.1016/0002-8703(78)90129-1.
The effects of verapamil on electrophysiologic parameters of the ventricle were studied during acute coronary occlusion in anesthetized open-chest dogs. Those parameters measured in the study were idioventricular automaticity, ventricular conduction, and fibrillation threshold. The incidence of rapidly repetitive beats and fibrillation induced by two successive premature beats was also studied. Verapamil significantly decreased idioventricular automaticity (in five dogs), improved conduction through the ischemic area (in six dogs), and increased fibrillation threshold of the ischemic ventricular (in eight dogs). The drug was effective in abolishing rapidly repetitive beats and fibrillation induced by closely coupled premature beats during acute coronary occlusion. Rapidly repetitive beats occurred in nine out of 15 dogs and these repetitive beats were degenerated into fibrillation in seven dogs before verapamil. Following pretreatment with the drug, rapidly repetitive beats and fibrillation occurred in none of the 15 dogs. The results indicate that verapamil can be very effective against ventricular arrhythmias occurring in association with myocardial infarction.
在麻醉开胸犬急性冠状动脉闭塞期间，研究了维拉帕米对心室电生理参数的影响。该研究中测量的参数有心室自主节律、心室传导和颤动阈值。还研究了由两个连续早搏诱发的快速重复搏动和颤动的发生率。维拉帕米显著降低了心室自主节律（5只犬），改善了通过缺血区的传导（6只犬），并提高了缺血心室的颤动阈值（8只犬）。该药在急性冠状动脉闭塞期间有效消除了由紧密偶联早搏诱发的快速重复搏动和颤动。15只犬中有9只出现快速重复搏动，在给予维拉帕米前，其中7只犬的这些重复搏动恶化为颤动。经该药预处理后，15只犬均未出现快速重复搏动和颤动。结果表明，维拉帕米对与心肌梗死相关的室性心律失常可能非常有效。
