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Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.

作者信息

Sinensky M, Logel J

出版信息

J Biol Chem. 1983 Jul 25;258(14):8547-9.

PMID:6553055
Abstract

Mevinolin is demonstrated to inhibit the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in Chinese hamster ovary cells. Evidence is presented that this effect of mevinolin is not general to degradation of total cellular proteins and is not due to the block to mevalonate synthesis produced by this compound.

摘要

相似文献

1
Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.
J Biol Chem. 1983 Jul 25;258(14):8547-9.
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Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase.缺乏3-羟基-3-甲基戊二酰辅酶A还原酶的中国仓鼠卵巢细胞突变克隆。
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Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.在UT-1细胞中，3-羟基-3-甲基戊二酰辅酶A还原酶基因发生扩增，但53 kDa蛋白的基因未扩增。
J Biol Chem. 1983 Jul 10;258(13):8462-9.

引用本文的文献

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Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.两种多跨内质网蛋白HMG-CoA还原酶和Insig-1在前往蛋白酶体降解的途中发生错位。
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J Clin Invest. 1985 Nov;76(5):1748-54. doi: 10.1172/JCI112165.
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Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites.
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Biochem J. 1988 Oct 1;255(1):61-7. doi: 10.1042/bj2550061.
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Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum.3-羟基-3-甲基戊二酰辅酶A还原酶膜结构域中八个跨膜区的免疫学证据：对其在内质网中酶降解的影响
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