González-Sastre F, Rodés M, Sabater J, Segura E
An Esp Pediatr. 1978 Jan;11(1):13-22.
The development of the central nervous system has been verified using biochemical techniques in two premature infants with intrauterine growth retardation. In both cases a retard of brain growth and maturity was detected. In the case less affected alterations consisted in a decrease in size of forebrain and cerebellum and a diminution of the DNA in cerebrum. In the other case sizes of cerebrum, cerebellum and brain stem were markedly reduced. The values of DNA and RNA were also lower than in controls being cerebellum and brain stem the more altered regions. The lipid composition of cerebrum, cerebellum and brain stem is also reported for both cases.
利用生化技术在两名患有宫内生长迟缓的早产儿身上验证了中枢神经系统的发育情况。在这两个病例中，均检测到脑生长和成熟延迟。在受影响较小的病例中，改变包括前脑和小脑尺寸减小以及大脑中DNA减少。在另一个病例中，大脑、小脑和脑干的尺寸明显减小。DNA和RNA的值也低于对照组，小脑和脑干是变化更大的区域。还报告了这两个病例大脑、小脑和脑干的脂质组成情况。
