药物的蛋白质结合
Protein binding of drugs.
作者信息
Heald A F, Singhvi S M
出版信息
Ann Clin Lab Sci. 1978 May-Jun;8(3):239-43.
PMID:655609
Abstract
Basic considerations involved in the interaction of drugs with proteins are reviewed. The important role of the concentration of unbound drug in determining therapeutic and toxicologic effects is emphasized. Ultra-filtration is suggested to be the method of choice for the determination of concentrations of unbound drug in plasma in clinical practice.
摘要
本文综述了药物与蛋白质相互作用的基本考量因素。强调了游离药物浓度在决定治疗和毒理效应方面的重要作用。建议在临床实践中，超滤法是测定血浆中游离药物浓度的首选方法。
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