Son'kin B Ia, Bukatina A E
Biofizika. 1983 Sep-Oct;28(5):886-8.
Vanadate (0.1 mM) reduces tension of glycerinated rabbit psoas muscle fibers, shifts tension--pCa curve to lower pCa, increases the rate constant of delayed tension development and changes dependence of this rate constant on the level of Ca2+-activation. Vanadate influence stops the increase of the rate constant with the rise of Ca++-activated tension. Since actin-myosin-ADP complex is dissociated by vanadate, the muscle performance at low activation levels is supposed to be conditioned largely by the cross-bridges interacting with actin of the actin blocks switched on by myosin-ADP. Kinetics of such cross-bridges differs from that of the cross bridges interacting with actin activated by Ca++ binding to troponin C.
钒酸盐（0.1毫摩尔）可降低甘油处理的兔腰大肌纤维的张力，将张力-pCa曲线移至较低的pCa值，增加延迟张力发展的速率常数，并改变该速率常数对Ca2+激活水平的依赖性。钒酸盐的影响会随着Ca++激活张力的升高而停止速率常数的增加。由于肌动蛋白-肌球蛋白-ADP复合物会被钒酸盐解离，因此低激活水平下的肌肉性能在很大程度上被认为是由与肌球蛋白-ADP开启的肌动蛋白块中的肌动蛋白相互作用的横桥所决定的。这种横桥的动力学与通过Ca++与肌钙蛋白C结合而激活的与肌动蛋白相互作用的横桥的动力学不同。
