Magnussen C R, Jacobson M T
Infect Control. 1984 Feb;5(2):88-92. doi: 10.1017/s0195941700059014.
The epidemiology of endemic gentamicin- and tobramycin-resistant gram-negative bacilli at a community hospital was analyzed over a one-year period three years following an original analysis at the same hospital. The frequency and distribution of resistant organisms remained stable over the time spanning the two studies. Only 2.8% of all gram-negative bacilli were resistant to gentamicin or tobramycin, and the majority of resistant isolates were non-Enterobacteriaceae. The respiratory and urinary tracts remained the body sites most prone to harbor resistant organisms. Risk analysis using a matched comparison group again revealed prior treatment with an aminoglycoside to be the only significant factor pre-disposing to acquisition of resistant gram-negative bacilli. This analysis indicates that community hospitals may not be important reservoirs of endemic aminoglycoside-resistant gram-negative bacilli, and reconfirms the observation that each hospital must define its own pattern of aminoglycoside resistance and unique risk factors.
在一家社区医院对庆大霉素和妥布霉素耐药的革兰氏阴性杆菌的流行病学进行了分析，此次分析是在同一医院首次分析三年后的一年期间进行的。在两项研究的时间跨度内，耐药菌的频率和分布保持稳定。所有革兰氏阴性杆菌中只有2.8%对庆大霉素或妥布霉素耐药，且大多数耐药菌株为非肠杆菌科细菌。呼吸道和泌尿道仍然是最容易携带耐药菌的身体部位。使用匹配对照组进行的风险分析再次表明，先前使用氨基糖苷类药物治疗是获得耐药革兰氏阴性杆菌的唯一重要易感因素。该分析表明，社区医院可能不是地方性氨基糖苷类耐药革兰氏阴性杆菌的重要储存库，并再次证实了每家医院都必须确定自己的氨基糖苷类耐药模式和独特风险因素这一观察结果。
