Parsons L C, Shogan J S
Heart Lung. 1984 Jul;13(4):372-80.
The findings of this clinical study suggest that the ETTS/MH procedure could be safely performed upon patients with severe closed head injuries whose baseline measurements of MICP were within the range of 0 to 20 mm Hg, provided the CPP was maintained at 50 mm Hg or greater. The advantages of performing the ETTS/MH procedure upon intubated patients far outweigh the possible disadvantages. The removal of pulmonary mucus plugs and secretions, which subsequently prevents hypercarbia and hypoxemia, is very important to the patient's recovery. In most situations, stimulation of the cough reflex through ETTS or even MH can help prevent atelectasis, a frequent pulmonary complication of neurologically depressed patients. Atelectasis can result in hypoxia that may adversely affect the cerebrovascular status. In addition, the results of this study suggest that multiple MHs after the third and subsequent ETTSs should be extended to a longer time interval, perhaps 60 seconds, in order that the physiologic measurements of MABP, MICP, CPP, and HR more closely approach the baseline levels. Also it is suggested that nurses performing the ETTS/MH procedure delay initiation of levels of physiologic function used to assess cerebrovascular status are reached.
这项临床研究结果表明,对于闭合性重度颅脑损伤且颅内压基线测量值在0至20毫米汞柱范围内的患者,只要将脑灌注压维持在50毫米汞柱或更高水平,就可以安全地实施经气管内吸引/机械通气(ETTS/MH)操作。对插管患者实施ETTS/MH操作的优点远远超过可能存在的缺点。清除肺部黏液栓和分泌物,进而预防高碳酸血症和低氧血症,对患者的康复非常重要。在大多数情况下,通过ETTS甚至MH刺激咳嗽反射有助于预防肺不张,这是神经功能抑制患者常见的肺部并发症。肺不张可导致缺氧,可能对脑血管状况产生不利影响。此外,本研究结果表明,在第三次及后续ETTS之后进行多次MH时,应将时间间隔延长至更长,或许为60秒,以便平均动脉压(MABP)、颅内压(MICP)、脑灌注压(CPP)和心率(HR)的生理测量值更接近基线水平。还建议实施ETTS/MH操作的护士延迟启动评估脑血管状况的生理功能水平测定。