Rudy E B, Turner B S, Baun M, Stone K S, Brucia J
School of Nursing, Case Western Reserve University, Cleveland, OH 44106.
Heart Lung. 1991 Nov;20(6):667-74.
The purpose of this study was to determine the method of endotracheal suctioning (ETS) that resulted in the least compromise to the cerebrovascular status of adult patients with severe head injuries. A two-group (two vs three ETS), two-protocol (100% tidal volume [VT] vs 135% VT) design was used. The dependent variables were mean intracranial pressure (MICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP), heart rate (HR), and oxygen saturation (SaO2). By random assignment, 14 subjects were in the two-ETS group and 16 subjects were in the three-ETS group. Intracranial pressure response to ETS in these patients with head injury can be characterized as falling into three patterns: (1) a rise in baseline beginning with ETS and continuing throughout the ETS sequences; (2) intracranial pressure spiking during the suctioning component of the protocol; (3) a combination of both a rising baseline and spiking. There was a significant (p less than or equal to 0.001) increase from baseline for both two- and three-ETS groups with both hyperoxygenation protocols (100% VT vs 135% VT) for MICP, MAP, HR, and CPP. No significant difference was found for SaO2 for either of the protocols regardless of number of suction passes. No significant differences were found between two- and three-ETS groups for any of the dependent variables. All groups, however, regardless of number of suction passes, demonstrated a cumulative increase in MICP, MAP, and CPP with each consecutive suction sequence.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是确定对重度颅脑损伤成年患者脑血管状态影响最小的气管内吸痰(ETS)方法。采用两组(两次与三次ETS)、两种方案(100%潮气量[VT]与135%VT)的设计。因变量为平均颅内压(MICP)、平均动脉压(MAP)、脑灌注压(CPP)、心率(HR)和氧饱和度(SaO2)。通过随机分组,14名受试者进入两次ETS组,16名受试者进入三次ETS组。这些颅脑损伤患者对ETS的颅内压反应可分为三种模式:(1)从ETS开始基线上升并在整个ETS过程中持续;(2)在方案的吸痰部分颅内压飙升;(3)基线上升和飙升两者皆有。对于MICP、MAP、HR和CPP,两次和三次ETS组在两种高氧方案(100%VT与135%VT)下,与基线相比均有显著(p≤0.001)升高。无论吸痰次数如何,两种方案的SaO2均未发现显著差异。两次和三次ETS组在任何因变量上均未发现显著差异。然而,所有组无论吸痰次数多少,随着连续的吸痰序列,MICP、MAP和CPP均呈现累积升高。(摘要截断于250字)