Shkinev A V, Gagel'gans A I, Iukel'son L Ia, Tashmukhamedov B A
Biull Eksp Biol Med. 1978 Apr;85(4):422-4.
A study was made of the action of various concentrations of cytotoxin (C), free of phospholipase A admixtures, on the respiration, oxidative phosphorylation of the rat liver mitochondria and their "ghosts", and also on the permeability of their internal membranes for various ions. Low C concentrations (10--25 micrometer) failed to influence the functional parameters of the intact mitochondria, but sharply increased the permeability of the internal membranes for monovalent ions. Apparently the uncoupling action of C on the mitochondrial "ghosts" was caused by the formation in the membrane of nonspecific conductivity "canals" with poor selectivity to the ion size and charge.
对不含磷脂酶A混合物的各种浓度细胞毒素（C）作用于大鼠肝脏线粒体及其“空壳”的呼吸、氧化磷酸化，以及其内膜对各种离子的通透性进行了研究。低浓度的C（10 - 25微米）未影响完整线粒体的功能参数，但显著增加了内膜对单价离子的通透性。显然，C对线粒体“空壳”的解偶联作用是由膜中形成的对离子大小和电荷选择性较差的非特异性导电“通道”所致。
