鸟苷三磷酸（GTP）与真核起始因子eIF-2的γ亚基相互作用。
GTP interacts with the gamma-subunit of eukaryotic initiation factor eIF-2.
作者信息
Kurzchalia T V, Bommer U A, Babkina G T, Karpova G G
出版信息
FEBS Lett. 1984 Oct 1;175(2):313-6. doi: 10.1016/0014-5793(84)80758-9.
PMID:6566615
Abstract
Eukaryotic initiation factor eIF-2 is an oligomeric protein consisting of three different subunits. During initiation of protein synthesis eIF-2 interacts with GTP, Met-tRNAf and 40 S ribosomal subunit. By affinity labeling with a photo-reactive GTP analogue it was shown that in the binary complex [eIF-2 X GTP] GTP is in contact with the gamma-subunit of eIF-2.
摘要
真核生物起始因子eIF-2是一种由三个不同亚基组成的寡聚蛋白。在蛋白质合成起始过程中，eIF-2与GTP、甲硫氨酰-tRNAf和40S核糖体亚基相互作用。通过用一种光反应性GTP类似物进行亲和标记表明，在二元复合物[eIF-2×GTP]中，GTP与eIF-2的γ亚基接触。
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