Bleehen T
Br J Pharmacol. 1978 Apr;62(4):573-7. doi: 10.1111/j.1476-5381.1978.tb07764.x.
1 The activity produced by the adenine nucleotides adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) and by potassium, acetylcholine (ACh), 5-hydroxytryptamine (5-HT) and bradykinin when applied to an exposed blister base on the ear of anaesthetized rabbits or intra-arterially to anaesthetized cats was investigated in multiple strands dissected from the auricular-temporal and saphenous nerves of rabbits and cats, respectively. 2 In the rabbit preparation potassium and the adenine nucleotides produced activity in the nerve fibres. The effects of these substances were produced in comparable dose ranges; threshold effects being produced by potassium at a concentration of 13 mM and by ADP at a concentration of 4 mM. ACh, 5-HT and bradykinin were inactive at similar or higher concentrations. 3 In the cat preparation all the substances tested produced activity in the nerve fibres. The adenine nucleotides were comparatively less potent than ACh, 5-HT or bradykinin, but had greater potency than potassium. 4 It was concluded that the adenine nucleotides do possess effects on afferent nerve terminals or fibres and thus resemble other known algogenic substances such as potassium, ACh, 5-HT and bradykinin.
1 研究了三磷酸腺苷（ATP）、二磷酸腺苷（ADP）、一磷酸腺苷（AMP）以及钾、乙酰胆碱（ACh）、5-羟色胺（5-HT）和缓激肽，分别应用于麻醉兔耳部暴露的水疱基部或经动脉注入麻醉猫体内时，在从兔和猫的耳颞神经及隐神经分离出的多条神经束中所产生的活性。2 在兔的实验准备中，钾和腺嘌呤核苷酸在神经纤维中产生活性。这些物质在相当的剂量范围内产生作用；钾浓度为13 mM、ADP浓度为4 mM时产生阈效应。乙酰胆碱、5-羟色胺和缓激肽在相似或更高浓度时无活性。3 在猫的实验准备中，所有测试物质在神经纤维中均产生活性。腺嘌呤核苷酸的效力相对低于乙酰胆碱、5-羟色胺或缓激肽，但比钾的效力更强。4 得出的结论是，腺嘌呤核苷酸确实对传入神经末梢或纤维有作用，因此类似于其他已知的致痛物质，如钾、乙酰胆碱、5-羟色胺和缓激肽。
