Israël L, Hajji F, Rigaut J P, Amouroux J
Cancer Immunol Immunother. 1984;18(1):24-8. doi: 10.1007/BF00205395.
A series of 43 patients (median age 57 years, range 39-73) underwent biopsy of the thymic area during resection for primary lung cancer (16 with negative nodes and 27 with positive nodes). In 22 cases in which study of lymphocyte subpopulations was possible T6 precursor thymocytes were found (mean 57%). T4 and T8 cells were present in proportions of 53% and 47%, respectively, equally distributed between T6 and T3 cells. A well-defined lobular structure was found in 11 cases and active thymic tissue with poorly defined lobules in 21 cases. There was no correlation of active thymus tissue either with age or with lymph node status. It is hypothesized that thymic tissue undergoes regeneration in response to tumor development, 50% of thymocytes being of the suppressor type in early tumors. Thymic structure in advanced cancer has not yet been studied.
43例患者（中位年龄57岁，范围39 - 73岁）在原发性肺癌切除术中接受了胸腺区域活检（16例淋巴结阴性，27例淋巴结阳性）。在22例可行淋巴细胞亚群研究的病例中，发现了T6前体胸腺细胞（平均57%）。T4和T8细胞分别占53%和47%，在T6和T3细胞之间均匀分布。11例发现明确的小叶结构，21例发现小叶界限不清的活跃胸腺组织。活跃胸腺组织与年龄或淋巴结状态均无相关性。据推测，胸腺组织会因肿瘤发展而发生再生，早期肿瘤中50%的胸腺细胞为抑制型。晚期癌症中的胸腺结构尚未研究。
