重症肌无力诊断试验的比较

Comparison of diagnostic tests in myasthenia gravis.

作者信息

Nicholson G A, McLeod J G, Griffiths L R

出版信息

Clin Exp Neurol. 1983;19:45-9.

Abstract

Results of 3 tests, intravenous edrophonium chloride, EMG, and acetylcholine receptor antibody testing, were compared in patients with generalised and ocular myasthenia gravis. None of the 3 tests was positive in any patient with a diagnosis other than myasthenia. However, equivocal results were obtained with edrophonium and EMG testing in some patients with myasthenia gravis and in patients with other diseases. It is concluded from this survey that antibody and edrophonium testing were equally efficient in detecting generalised myasthenia gravis. Edrophonium testing was superior in ocular myasthenia gravis. Although the yields from each test varied, all 3 tests were needed for the evaluation of some myasthenia gravis patients as each test may provide additional information.

摘要

对全身性和眼肌型重症肌无力患者进行了三项检查，即静脉注射氯化依酚氯铵试验、肌电图检查和乙酰胆碱受体抗体检测，并对结果进行了比较。除重症肌无力外，其他任何诊断的患者三项检查均无阳性结果。然而，在一些重症肌无力患者和其他疾病患者中，依酚氯铵试验和肌电图检查结果不明确。本次调查得出的结论是，抗体检测和依酚氯铵试验在检测全身性重症肌无力方面效率相当。依酚氯铵试验在眼肌型重症肌无力中更具优势。尽管每项检查的阳性率有所不同，但评估某些重症肌无力患者时三项检查都需要，因为每项检查都可能提供额外信息。