Kalnins R M, Berkovic S F, Bladin P F
Clin Exp Neurol. 1984;20:189-202.
Two cases of central pontine myelinolysis with extensive extrapontine lesions are described. Both occurred in patients with longstanding quadriplegia in whom severe hyponatraemia, occurring in a setting of respiratory infection, was rapidly corrected with hypertonic saline. The extrapontine lesions resembled those described in extrapontine myelinolysis, but the possibility that an anoxic-ischaemic component may have contributed is discussed. The clinical data in these two cases are consistent with the mounting body of clinical and experimental evidence that disturbances of sodium balance may be an important cause of central pontine and extrapontine myelinolysis.
本文描述了两例伴有广泛脑桥外病变的中央桥脑髓鞘溶解症。两例均发生于长期四肢瘫痪患者，他们在呼吸道感染时出现严重低钠血症，随后用高渗盐水迅速纠正。脑桥外病变与脑桥外髓鞘溶解症中所描述的病变相似，但本文讨论了缺氧缺血因素可能起作用的可能性。这两例的临床资料与越来越多的临床和实验证据一致，即钠平衡紊乱可能是中央桥脑和脑桥外髓鞘溶解症的一个重要病因。
