[Disorders of the kallikrein-kinin, renin-angiotensin and sympathetic-adrenal systems in chronic kidney failure patients during hemodialysis treatment].

Blood plasma renin activity, blood adrenaline and noradrenaline concentrations, and the kallikrein-kinin system were studied in 48 patients with chronic renal failure (CRF). Thirty-five patients with normal blood pressure and controlled hypertension (group I) showed a decrease in blood plasma renin and kallikrein-kinin system deficiency. In 13 patients with uncontrollable hypertension (group II), the renin-angiotensin and sympathoadrenal systems were found to be activated in the presence of the kallikrein-kinin system deficiency. Disorders of normal interrelations between the renin-angiotensin, sympathoadrenal and kallikrein-kinin systems in patients with CRF are determined to a significant degree by upset regulation of the metabolism of biologically active substances by the lungs in connection with the occurrence of microemboli in the pulmonary circulation during hemodialysis.