[Type A adenocarcinoma grafted into C3H/he mice subjected to treatment with various antineoplastic agents. II. Histopathological and ultrastructural study].

We studied the histopathological and ultrastructural modifications which the adenocarcinoma type A grafted to C3 H/he-M mice manifested on being treated with vincristine, prospidium chloride and adriamycin. With M/O the tumors treated with prospidium chloride and adriamycin showed a greater proportion of connective stroma and numerous extensive parenchymatous necrosis. Ultrastructurally, in these groups, atypical mitoses were observed with multiple chromosomal fragmentations which can be related to the pharmacological action mechanism. A decrease in the number of viral particles was seen throughout the treatment.