LeGeros R Z, Silverstone L M, Daculsi G, Kerebel L M
J Dent Res. 1983 Feb;62(2):138-44. doi: 10.1177/00220345830620021101.
In vitro caries-like lesion formation in F-containing tooth enamel (shark) showed a lower depth of penetration compared to that in human enamel (42 vs. 100%). After longer periods of exposure, the depth of penetration in shark enamel is only 33% relative to that in human enamel. The extent of dissolution in acetate buffer for powdered human enamel and for synthetic F-free calcium-carbonated-apatites was greater than for powdered shark enamel and for synthetic F-containing apatites. These results suggest that the cariostatic action of fluoride may be explained in terms of a combination of two effects: (a) the stabilizing effect against acid dissolution (caries) when fluoride is incorporated in the tooth mineral (apatite), and (b) a greater degree of remineralization (repair) in the presence of F solution.
在含氟牙釉质（鲨鱼）中形成的体外类龋损病变与人类牙釉质相比，其渗透深度较低（42% 对 100%）。暴露较长时间后，鲨鱼牙釉质的渗透深度相对于人类牙釉质仅为 33%。粉末状人类牙釉质和合成无氟碳酸钙磷灰石在醋酸盐缓冲液中的溶解程度大于粉末状鲨鱼牙釉质和合成含氟磷灰石。这些结果表明，氟化物的防龋作用可以用两种效应的组合来解释：(a) 当氟化物掺入牙齿矿物质（磷灰石）中时对酸溶解（龋齿）的稳定作用，以及 (b) 在氟溶液存在下更高程度的再矿化（修复）。
