Smith A G, Prentice A G, Lucie N P, Dagg J H
Cancer. 1983 Jun 1;51(11):2031-4. doi: 10.1002/1097-0142(19830601)51:11<2031::aid-cncr2820511112>3.0.co;2-n.
Two cases of Ph1-positive acute lymphoblastic leukemia (ALL) and one case of lymphoid blast crisis (LyBc) of chronic granulocytic leukemia (CGL) treated with standard chemotherapy for ALL are presented. Hematologic remissions lasting 6, 12, and 15 months were achieved in all cases. Meningeal relapse occurred in all three, terminating remission in two cases and occurring immediately after systemic relapse in the third. No CNS-prophylaxis was given to the patient who relapsed at six months. Methotrexate (MTX) alone or combined with cranial irradiation formed the prophylaxis given in the other cases. Experience of these patients together with an analysis of reported cases of Ph1 ALL and CGL-LyBc suggests CNS-prophylaxis may prolong first remission. A large scale trial of this appears indicated.
本文报告了2例Ph1阳性急性淋巴细胞白血病（ALL）和1例慢性粒细胞白血病（CGL）的淋巴母细胞危象（LyBc）采用ALL标准化疗方案治疗的情况。所有病例均实现了持续6个月、12个月和15个月的血液学缓解。3例均发生了脑膜复发，其中2例缓解终止，第3例在全身复发后立即发生。6个月复发的患者未接受中枢神经系统预防治疗。其他病例采用单独甲氨蝶呤（MTX）或联合头颅照射进行预防。这些患者的经验以及对报道的Ph1 ALL和CGL-LyBc病例的分析表明，中枢神经系统预防可能会延长首次缓解期。似乎有必要对此进行大规模试验。
