人类基底动脉中的多巴胺受体。

Dopamine receptors in human basilar arteries.

作者信息

Forster C, Drew G M, Hilditch A, Whalley E T

出版信息

Eur J Pharmacol. 1983 Feb 18;87(2-3):227-35. doi: 10.1016/0014-2999(83)90332-1.

Abstract

After phenoxybenzamine (10(-5) M), pretreatment, and in the presence of propranolol (10(-6) M) and indomethacin (2.8 X 10(-6) M), dopamine caused a marked concentration-dependent relaxation of isolated strips of human basilar artery contracted with PGF2 alpha. This effect was mimicked by apomorphine, 6,7-ADTN and SK&F 38393, but N,N-diethyl dopamine, N,N-di-n-propyl-dopamine and 5,6-ADTN caused only slight relaxation. (+)-Butaclamol, cis-alpha-flupenthixol, fluphenazine and haloperidol competitively antagonised the relaxant effects of dopamine, but sulpiride was ineffective in concentrations as high as 1.3 X 10(-4) M. These findings show that the dopamine receptors in the human basilar artery closely resemble those in the smooth muscle of the rabbit isolated mesenteric and splenic arteries, and the dog renal and mesenteric arteries in vivo, but differ from those located presynaptically on sympathetic nerve terminals.

摘要

在给予苯氧苄胺（10⁻⁵ M）预处理后，并且在普萘洛尔（10⁻⁶ M）和吲哚美辛（2.8×10⁻⁶ M）存在的情况下，多巴胺使与前列腺素F2α预收缩的人基底动脉离体条带产生明显的浓度依赖性舒张。阿扑吗啡、6,7 - 二羟基硫代去甲肾上腺素（6,7 - ADTN）和SK&F 38393可模拟此效应，但N,N - 二乙多巴胺、N,N - 二正丙基多巴胺和5,6 - 二羟基硫代去甲肾上腺素（5,6 - ADTN）仅引起轻微舒张。（+） - 布他拉莫、顺式α - 氟哌噻吨、氟奋乃静和氟哌啶醇竞争性拮抗多巴胺的舒张作用，但舒必利在高达1.3×10⁻⁴ M的浓度下无效。这些发现表明，人基底动脉中的多巴胺受体与兔离体肠系膜和脾动脉、犬体内肾动脉和肠系膜动脉平滑肌中的多巴胺受体非常相似，但与位于交感神经末梢突触前的多巴胺受体不同。