泼尼松龙清除率：口腔水疱糜烂性疾病患者糖皮质激素疗效的一个可能决定因素。
Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases.
作者信息
Lozada F, Frey F J, Benet L Z
出版信息
J Dent Res. 1983 May;62(5):575-7. doi: 10.1177/00220345830620051401.
PMID:6573375
Abstract
The pharmacokinetics of prednisolone were determined in 12 patients with oral vesiculo-erosive diseases. The bioavailability of prednisone in these patients exhibited a low intersubject variability, while the metabolic clearance rate of total and of unbound prednisolone varied considerably from patient to patient.
摘要
在12例口腔水疱糜烂性疾病患者中测定了泼尼松龙的药代动力学。这些患者中泼尼松的生物利用度个体间变异性较低，而总泼尼松龙和游离泼尼松龙的代谢清除率在患者之间差异很大。
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