Pollack A, Block N L, Stover B J, Irvin G L, Fuentes M P, Claflin A J, Malinin T I
J Natl Cancer Inst. 1983 May;70(5):907-14.
Tumors grown in diethylstilbestrol diphosphate (DES)-treated rats grew significantly more slowly than tumors grown in orchiectomized animals, and tumors grown in orchiectomized animals grew significantly more slowly than tumors grown in controls (intact male rats). When these tumors (phase I) were dispersed and reimplanted into DES-treated, orchiectomized, or control rats in all possible combinations (phase II), a partial selection of androgen-insensitive cells was observed in tumors grown in DES-treated animals. Tumors grown in DES-treated phase I animals responded significantly less to DES treatment or orchiectomy in phase II. In contrast, tumors from phase I orchiectomized animals showed the same responses to orchiectomy in phase II. Since the administration of exogenous testosterone propionate prevented the growth rate inhibitory effects of both DES treatment and orchiectomy, the added effect of DES seemed to be antiandrogenic.
在己烯雌酚二磷酸酯（DES）处理的大鼠体内生长的肿瘤，其生长速度明显慢于在去势动物体内生长的肿瘤，而去势动物体内生长的肿瘤，其生长速度又明显慢于对照组（完整雄性大鼠）体内生长的肿瘤。当这些肿瘤（第一阶段）被分散并以所有可能的组合方式重新植入经DES处理、去势或对照大鼠体内（第二阶段）时，在经DES处理的动物体内生长的肿瘤中观察到了部分雄激素不敏感细胞的选择。在第一阶段经DES处理的动物体内生长的肿瘤，在第二阶段对DES处理或去势的反应明显较小。相比之下，第一阶段去势动物的肿瘤在第二阶段对去势表现出相同的反应。由于给予外源性丙酸睾酮可阻止DES处理和去势对生长速度的抑制作用，DES的附加作用似乎是抗雄激素的。
