临界高血压和原发性高血压患者体内的血栓素B2
Thromboxane B2 in borderline and essential hypertensive patients.
作者信息
Hornych A, Safar M, Bariéty J, Simon A, London G, Levenson J
出版信息
Prostaglandins Leukot Med. 1983 Feb;10(2):145-55. doi: 10.1016/s0262-1746(83)80005-5.
Thromboxane B2 (TxB2) was measured in the venous and arterial plasma and in the urine of 15 borderline and 15 sustained essential hypertensive patients, and in the plasma and urine of 12 control normotensive age-matched subjects. Plasma and urine thromboxane B2 were significantly higher in both the borderline and sustained hypertensives than in the control normotensives. There was a significant positive correlation between urinary (i.e. renal)TxB2 excretion and the glomerular filtration rate, and between urinary TxB2 excretion and sodium excretion in the hypertensive but not in the normotensive subjects. Thromboxane A2 participates in pressure natriuresis.
在15例临界高血压患者、15例持续性原发性高血压患者的静脉血和动脉血浆以及尿液中，以及在12例年龄匹配的血压正常对照者的血浆和尿液中，检测了血栓素B2（TxB2）。临界高血压患者和持续性高血压患者的血浆和尿液血栓素B2均显著高于血压正常的对照者。在高血压患者中，尿（即肾）TxB2排泄与肾小球滤过率之间以及尿TxB2排泄与钠排泄之间存在显著正相关，而在血压正常者中则无此相关性。血栓素A2参与压力性利钠作用。
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