Mittler J C
Arch Androl. 1983 Mar;10(1):47-50. doi: 10.3109/01485018308990170.
Production of 4-androstene-7 alpha,17 beta-diol-3-one (7 alpha-hydroxytestosterone) from testosterone was measured in seminiferous tubule and interstitial fractions of rat testis. In adults, specific activity of the 7 alpha-hydroxylase was about 10 times higher in interstitial cells than in seminiferous tubules, but tubule production was a significant portion of the total. Seminiferous tubule 7 alpha-hydroxylase was not detectable in weanlings. Also, we confirmed that 7 alpha-hydroxytestosterone inhibits the activity of the 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase active on testosterone and suggest a role in maturational changes.
在大鼠睾丸的生精小管和间质部分测定了由睾酮生成4-雄烯-7α,17β-二醇-3-酮（7α-羟基睾酮）的情况。在成年大鼠中，7α-羟化酶的比活性在间质细胞中比在生精小管中高约10倍，但小管生成量占总量的很大一部分。在断奶幼鼠中未检测到生精小管7α-羟化酶。此外，我们证实7α-羟基睾酮可抑制对睾酮有活性的5α-还原酶和3α-羟基类固醇脱氢酶的活性，并提示其在成熟变化中起作用。
