Cook B A, Sinnhuber J R, Thomas P J, Olson T A, Silverman T A, Jones R, Whitehead V M, Ruymann F B
Cancer. 1983 Jul 1;52(1):61-3. doi: 10.1002/1097-0142(19830701)52:1<61::aid-cncr2820520112>3.0.co;2-w.
Indicine N-oxide, a pyrrolizidine alkaloid, was given to a five-year-old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N-oxide toxicity.
indicine N-氧化物是一种吡咯里西啶生物碱，被给予一名患有难治性急性髓细胞白血病的五岁男孩。用药三天后，患者出现急性肝衰竭的体征和症状。用药九天后患者死亡，尸检显示大量肝坏死。该患者观察到的急性肝衰竭可能继发于 indicine N-氧化物毒性。
