Hildreth N G, Kelsey J L, Eisenfeld A J, LiVolsi V A, Holford T R, Fischer D B
J Natl Cancer Inst. 1983 Jun;70(6):1027-31.
One hundred and forty-eight postmenopausal breast cancer cases and 585 postmenopausal controls were included in an investigation of whether various risk factors for breast cancer are associated with the level of estrogen (E) receptor (ER) protein in the tumor. In an intracase analysis, the tumor ER level was positively associated with nulliparity, late age at first live birth, a history of benign breast disease, and having breast-fed at least 1 child and was negatively associated with previous use of E replacement therapy. A case-control analysis suggested that the first three variables, established risk factors for breast cancer, are associated with an increased risk for malignant breast tumors that are ER-positive but not for those that are ER-negative. This analysis did not provide a clear interpretation of the findings in the intracase comparisons with regard to prior breast-feeding and the use of E replacement therapy.
148例绝经后乳腺癌病例和585例绝经后对照者纳入了一项关于乳腺癌的各种危险因素是否与肿瘤中雌激素（E）受体（ER）蛋白水平相关的调查。在病例内分析中，肿瘤ER水平与未生育、首次生育年龄晚、良性乳腺疾病史以及曾哺乳至少1个孩子呈正相关，与既往使用雌激素替代疗法呈负相关。病例对照分析表明，前三个变量作为已确定的乳腺癌危险因素，与雌激素受体阳性的恶性乳腺肿瘤风险增加相关，但与雌激素受体阴性的肿瘤无关。该分析并未对病例内比较中关于既往母乳喂养和雌激素替代疗法使用的结果给出明确解释。
