Heffez L, Doku H C, Carter B L, Feeney J E
Oral Surg Oral Med Oral Pathol. 1983 Apr;55(4):331-43. doi: 10.1016/0030-4220(83)90185-8.
Massive osteolysis is a rare, chronic disease characterized by the progressive dissolution of contiguous osseous structures. There is no regeneration following the osteolysis. Pathologic fracture often leads to its discovery. The etiology and pathophysiology of the disease remain obscure. Chemo- and radiotherapeutic attempts at arresting the osteolytic process are generally unsuccessful. Bone grafting has proved disappointing, as the graft usually undergoes osteolysis. A new case of facial bone involvement in a 13-year-old boy is presented. The literature is reviewed, and the clinical experience gained from treating the disease is discussed.
大量骨质溶解是一种罕见的慢性疾病，其特征为相邻骨质结构的进行性溶解。骨质溶解后不会再生。病理性骨折常导致该病被发现。该病的病因和病理生理学仍不清楚。试图通过化疗和放疗来阻止骨质溶解过程通常并不成功。骨移植已被证明令人失望，因为移植骨通常会发生骨质溶解。本文报告了一名13岁男孩面部骨骼受累的新病例。对相关文献进行了综述，并讨论了在治疗该疾病过程中获得的临床经验。
