D'Amaro J, van Rood J J, Rimm A A, Bortin M M
Tissue Antigens. 1983 Mar;21(3):184-91. doi: 10.1111/j.1399-0039.1983.tb00156.x.
A reassessment of HLA-A and B antigen associations in patients with severe aplastic anaemia confirmed the significantly elevated frequency of HLA-A2 in Caucasoid patients reported by Albert et al. (1976). In addition, a highly significant increase in the frequency of HLA-B14 in Italian patients was observed in an initial sample of 25 patients and confirmed in a second sample of 16 patients. This latter finding was cancelled out when the Italian Caucasoid patients were pooled with the non-Italian Caucasoid patients. These results suggest that the classification of populations as "Caucasoids", without examining their ethnic origins, may introduce a serious confounding error into HLA and disease studies.
对严重再生障碍性贫血患者的HLA - A和B抗原关联进行的重新评估，证实了阿尔伯特等人（1976年）报告的高加索患者中HLA - A2频率显著升高。此外，在25例患者的初始样本中观察到意大利患者中HLA - B14频率显著增加，并在16例患者的第二个样本中得到证实。当将意大利高加索患者与非意大利高加索患者合并时，后一发现被抵消。这些结果表明，在未考察种族起源的情况下将人群分类为“高加索人”，可能会在HLA与疾病研究中引入严重的混杂误差。
