Kim J E, Shklar G
J Periodontol. 1983 May;54(5):305-8. doi: 10.1902/jop.1983.54.5.305.
Forty male and female albino rats received a standardized gingival wound (gingivectomy) between the mandibular incisor teeth. One half of the animals received 60 I.U. of d-alpha-tocopheryl acetate daily, administered orally by pipette. An additional control group of 20 animals was not wounded and half of these animals received 60 I.U. of d-alpha-tocopheryl daily. Four animals in each of the two gingivectomy groups (Groups 1, 2) were sacrificed at periods of 1, 2, 4, 7 and 14 days following gingivectomy. Two animals in each of two control unwounded groups (Groups 3, 4) were sacrificed at similar times. Gingival healing was studied grossly and histologically. The animals receiving the vitamin E supplements healed more rapidly, with almost complete restoration of gingiva by 7 days. Complete healing was seen in both control and experimental groups by 14 days. Vitamin E was shown to accelerate gingival wound healing in experimental animals.
40只雄性和雌性白化大鼠在下颌切牙之间接受了标准化的牙龈伤口（牙龈切除术）。其中一半动物每天通过移液管口服60国际单位的d-α-生育酚醋酸酯。另外20只动物组成的对照组未受伤，其中一半动物每天接受60国际单位的d-α-生育酚。在牙龈切除术后1、2、4、7和14天，对两个牙龈切除组（第1组、第2组）中的每组4只动物实施安乐死。在两个未受伤的对照组（第3组、第4组）中的每组2只动物在相同时间实施安乐死。对牙龈愈合情况进行大体和组织学研究。补充维生素E的动物愈合更快，到7天时牙龈几乎完全恢复。到14天时，对照组和实验组均实现完全愈合。研究表明，维生素E可加速实验动物的牙龈伤口愈合。
