[单胺氧化酶抑制剂。II. N-环丙基色胺对牛血浆胺氧化酶的抑制作用]
[Substances inhibiting monoamine oxidase. II. Inhibition of bovine plasma amine oxidase by N-cyclopropyltryptamines].
作者信息
Chimenti F, Casanova M C, Zagarese V, Turin P, Sabatini S
出版信息
Farmaco Sci. 1983 Jun;38(6):425-8.
PMID:6575920
Abstract
In this paper, we report the inhibition constants obtained with N-cyclopropyl-5,6-dimethoxytryptamine and with N-cyclopropyl-6,7-dimethoxytryptamine on the activity of beef plasma amineoxidase. The inhibition constants are respectively: 0.3 x 10(-3) M and 0.65 x 10(-3) M. A dixon graph of the enzymic oxidation of benzylamine indicates a non-competitive inhibition of the enzyme by these dimethoxytryptamines.
摘要
在本文中，我们报告了N-环丙基-5,6-二甲氧基色胺和N-环丙基-6,7-二甲氧基色胺对牛肉血浆胺氧化酶活性的抑制常数。抑制常数分别为：0.3×10⁻³ M和0.65×10⁻³ M。苄胺酶促氧化的迪克森图表明这些二甲氧基色胺对该酶具有非竞争性抑制作用。
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