Lenhard L, Waite P M
N Z Med J. 1983 Aug 24;96(738):663-6.
This study was planned as a pilot study to determine to what extent acupuncture might help in severe cases of migraine and, if possible, to see whether the mechanism was endorphin mediated. The study was carried out on 16 subjects who had severe and regular migraine for more than five years (mean duration 24 years). The study lasted eight months and was divided into four blocks of two months each: pre-treatment, treatment block I, treatment block II, and post-treatment. It was double-blind and cross-over in design. Acupuncture was found to cause a significant change in the number of headaches and their duration, with 40% of the subjects showing a 50%-100% reduction. Although pain sensation was not altered, attacks were less severe and less often accompanied by nausea and vomiting. At no stage was there any difference between subjects receiving saline or naloxone so that the possibility of a non-endorphin mechanism must be considered.
本研究计划作为一项试点研究，以确定针灸在严重偏头痛病例中可能有多大帮助，并在可能的情况下，观察其作用机制是否由内啡肽介导。该研究针对16名患有严重且规律性偏头痛超过五年（平均病程24年）的受试者进行。研究持续了八个月，分为四个为期两个月的阶段：治疗前、治疗阶段I、治疗阶段II和治疗后。该研究采用双盲交叉设计。结果发现，针灸使头痛次数及其持续时间发生了显著变化，40%的受试者头痛次数减少了50%-100%。虽然疼痛感觉没有改变，但发作程度减轻，且较少伴有恶心和呕吐。在任何阶段，接受生理盐水或纳洛酮的受试者之间均无差异，因此必须考虑非内啡肽机制的可能性。
