Kinetics of fluorine in deciduous enamel after application of fluoride-containing varnish (Duraphat). II. A statistical approach to the design and evaluation of a clinical experiment.

The aim of this report is to discuss the design and technique for evaluation of an in vivo experiment on the kinetics of fluorine in deciduous enamel after application of fluorine-containing varnish (Duraphat). The analysis of variance technique used in the analysis of the results of the experiments is described in more detail than in the preceding report. The figure technique used in this report series is described. The method error study performed before carrying out the main experiment is analysed. A brief discussion follows about the consequences that different method errors have on the design of the experiment. The conclusion is that analysis of variance is a more reliable tool than multiple t-test, when evaluation of experiments is to be carried out.