Herrmann F, Komischke B, Odenwald E, Ludwig W D
Blut. 1983 Sep;47(3):157-63. doi: 10.1007/BF00320178.
Various monoclonal antibodies (mAbs) detecting certain different epitopes on myeloid cells (VIMD5, D5 D6, OKM1, Leu-M3, VIEG4, OKIa 1) have been used in combination with conventional markers (antihuman myeloid hetero-antiserum, FcIgG-receptors, C3d-receptors) to further define the phenotypic heterogeneity of myeloid leukemia. Subsequent leukemic samples from previously untreated patients with acute myeloid leukemia (AML) (51 adults, 24 children) and from nine adult patients in the acute phase of chronic myeloid leukemia (CML-BC) were studied. It was possible to demonstrate quantitative differences in the expression of antigens on the various leukemia subtypes which could be exploited for diagnosis. Furthermore our results revealed that there is a very close correlation between the different surface phenotypes and the types morphologically assessed according to FAB-criteria.
多种检测髓系细胞上某些不同表位的单克隆抗体（VIMD5、D5 D6、OKM1、Leu-M3、VIEG4、OKIa 1）已与传统标志物（抗人髓系异种抗血清、FcIgG受体、C3d受体）联合使用，以进一步明确髓系白血病的表型异质性。随后对来自先前未经治疗的急性髓系白血病（AML）患者（51名成人，24名儿童）以及9名慢性髓系白血病急性期（CML-BC）成年患者的白血病样本进行了研究。有可能证明不同白血病亚型上抗原表达的定量差异可用于诊断。此外，我们的结果显示，不同的表面表型与根据FAB标准进行形态学评估的类型之间存在非常密切的相关性。
