内吞作用中Fe+3与转铁蛋白的分离。酸性内体的作用。
Separation of Fe+3 from transferrin in endocytosis. Role of the acidic endosome.
作者信息
Rao K, van Renswoude J, Kempf C, Klausner R D
出版信息
FEBS Lett. 1983 Aug 22;160(1-2):213-6. doi: 10.1016/0014-5793(83)80969-7.
PMID:6576912
Abstract
NH4Cl and monensin, two agents which neutralize intracellular acidic compartments, block the segregation of iron from transferrin after endocytosis, while neither of these reagents affects internalization of diferric transferrin into the cell. In conclusion the molecular separation of iron from transferrin inside the cell requires a non-lysosomal acidic compartment.
摘要
氯化铵和莫能菌素这两种可中和细胞内酸性区室的试剂，会阻断内吞作用后铁从转铁蛋白的分离，而这两种试剂均不影响双铁转铁蛋白进入细胞的内化过程。总之，细胞内铁与转铁蛋白的分子分离需要一个非溶酶体酸性区室。
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