Haugh R M, Markesbery W R
Arch Neurol. 1983 Sep;40(9):560-3. doi: 10.1001/archneur.1983.04050080060011.
A 26-year-old woman had hyperphagia, obesity, aggressive behavior, visual hallucinations, reversal of wake-sleep patterns, hypothermia, hypothyroidism, and amenorrhea. She died of pancreatitis, probably secondary to hypothermia. Autopsy revealed a low-grade astrocytoma in the third ventricle and medial anterior and mid hypothalamus, primarily on the right. Although she exhibited thyroid and ovarian hypofunction, the patient had intact median eminence and pituitary function, suggesting end-organ failure, possibly of an autoimmune nature.
一名26岁女性出现食欲亢进、肥胖、攻击性行为、视幻觉、睡眠-清醒模式颠倒、体温过低、甲状腺功能减退和闭经。她死于胰腺炎，可能继发于体温过低。尸检发现第三脑室以及下丘脑前部内侧和中部有一个低度星形细胞瘤，主要位于右侧。尽管该患者表现出甲状腺和卵巢功能减退，但正中隆起和垂体功能完好，提示可能是自身免疫性的终末器官衰竭。
