Naclerio R M, Meier H L, Adkinson N F, Kagey-Sobotka A, Meyers D A, Norman P S, Lichtenstein L M
Eur J Respir Dis Suppl. 1983;128 (Pt 1):26-32.
An in vivo model system was developed to recover inflammatory mediators from the nose after antigen stimulation. In 105 experiments involving 35 subjects, antigen was introduced into the nose. Allergic individuals demonstrated an increase concentration of histamine, TAMe esterase and PgD2 during the physiologic changes of nasal obstruction and sneezing. Clinical symptoms and mediator release were highly correlated; moreover, the release of each mediator was significantly correlated to the others.
开发了一种体内模型系统，用于在抗原刺激后从鼻腔中回收炎症介质。在涉及35名受试者的105项实验中，将抗原引入鼻腔。过敏个体在鼻塞和打喷嚏的生理变化过程中，组胺、TAMe酯酶和PgD2的浓度升高。临床症状与介质释放高度相关；此外，每种介质的释放与其他介质的释放显著相关。
