[Effect of lasix on prostaglandins of the kidneys and lungs of rats with spontaneous hypertension].

Lasix effects on diuresis, natriuresis and pulmonary and renal prostaglandin biosynthesis and catabolism were examined in spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NTR). PGE2 and PGF2 biosynthesis from 14C-arachidonic acid, and 3H-PGF1 and PGE2 catabolism were measured in kidney and lung homogenates. Changes in PG metabolism were shown to be dependent on age, blood pressure and the time of lasix action. Decreased biosynthesis and increased catabolism were demonstrated for PGE2, and reverse changes were shown for the production and decay of PGF2 alpha. Reciprocal changes were demonstrated in renal and pulmonary PG metabolism, an evidence of inter-organ relationships between prostaglandin systems of the organs in question. SHRs and NTRs showed different response of renal and pulmonary PGs, natriuresis and diuresis to lasix administration.