血卟啉敏化的病毒RNA依赖性DNA聚合酶的光动力失活
Hematoporphyrin-sensitized photodynamic inactivation of viral RNA-dependent DNA polymerase.
作者信息
Munson B R, Fiel R J
出版信息
Res Commun Chem Pathol Pharmacol. 1977 Jan;16(1):175-8.
PMID:65786
Abstract
Visible light (6328A) was shown to inactivate RNA-dependent DNA polymerase activity of Moloney mouse leukemia virus, in the presence of hematoporphyrin. The same treatment on exogenous, template-initiation complex had no effect on enzyme activity. It was suggested that this enzyme may be the target of photodynamic inactivation of this and related viruses.
摘要
在血卟啉存在的情况下，可见光（6328埃）可使莫洛尼氏小鼠白血病病毒的RNA依赖性DNA聚合酶失活。对外源模板起始复合物进行相同处理对酶活性没有影响。有人提出，这种酶可能是该病毒及相关病毒光动力失活的靶点。
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