Bewtra C, Dewan N, O'Donahue W J
Acta Cytol. 1983 Sep-Oct;27(5):489-96.
In a prospective, double-blind, randomized study of cytologic changes found in pulmonary infarction, nine roentgenologically proven cases of pulmonary embolism were studied with sputum samples from the 1st to 26th postinfarction days. Maximum atypical cytologic changes were seen during the second and third postinfarction weeks. Specific cytologic features included three-dimensional clusters of glandular cells with enlarged nuclei and macronucleoli: they were malignant-appearing cells except for their inconsistent morphology, fewer numbers, transient appearance and lack of solitary atypical cells. A similar study in a canine model is discussed, and a case of pulmonary embolism with abnormal cytology and corresponding histology is presented.
在一项关于肺梗死细胞学变化的前瞻性、双盲、随机研究中，对9例经X线检查证实的肺栓塞病例在梗死发生后第1天至第26天采集痰液样本进行研究。在梗死发生后的第二和第三周观察到最大程度的非典型细胞学变化。特定的细胞学特征包括三维排列的腺细胞簇，细胞核增大且有大核仁：这些细胞除形态不一致、数量较少、短暂出现且缺乏单个非典型细胞外，看起来具有恶性特征。文中讨论了在犬模型中的类似研究，并展示了一例伴有异常细胞学及相应组织学表现的肺栓塞病例。
