单乙酸甘油酯和氯化钙对实验性氟乙酸钠中毒时酸碱平衡及存活情况的影响

The effect of monoacetin and calcium chloride on acid-base balance and survival in experimental sodium fluoroacetate poisoning.

作者信息

Taitelman U, Roy A, Raikhlin-Eisenkraft B, Hoffer E

出版信息

Arch Toxicol Suppl. 1983;6:222-7. doi: 10.1007/978-3-642-69083-9_40.

Abstract

Sodium fluoroacetate (compound "1080") was injected intravenously, 3 mmol/kg, to artificially-ventilated anesthetized cats. Blood pressure, ECG, acid-base parameters and serum ionized calcium were monitored in four groups of cats. Group A served as control. Group B cats were treated with calcium chloride to restore normal values of serum ionized calcium. Group C was given monoacetin (glyceryl monoacetate), 0.5 ml/kg every 30 min. Both monoacetin and calcium chloride were given to cats in group D. Fluoroacetate poisoning caused significant decrease in ionized calcium and severe metabolic acidosis with increased levels of lactate and pyruvate. The lactate to pyruvate ratio remained normal as long as there was no significant drop in blood pressure. Correction of blood ionized calcium prolonged survival from 94 to 166 min (group B). Monoacetin prolonged average survival time to 166 min. Metabolic acidosis was aggravated in monoacetin-treated animals (group C). Combined treatment with monoacetin and calcium chloride did not prolong mean survival time above 166 min.

摘要

将3 mmol/kg的氟乙酸钠（化合物“1080”）静脉注射到人工通气的麻醉猫体内。对四组猫监测血压、心电图、酸碱参数和血清离子钙。A组作为对照。B组猫用氯化钙治疗以恢复血清离子钙的正常值。C组每30分钟给予单乙酸甘油酯（甘油单乙酸酯），剂量为0.5 ml/kg。D组猫同时给予单乙酸甘油酯和氯化钙。氟乙酸钠中毒导致离子钙显著降低以及严重的代谢性酸中毒，乳酸和丙酮酸水平升高。只要血压没有显著下降，乳酸与丙酮酸的比值就保持正常。纠正血液离子钙可使存活时间从94分钟延长至166分钟（B组）。单乙酸甘油酯使平均存活时间延长至166分钟。单乙酸甘油酯治疗的动物（C组）代谢性酸中毒加重。单乙酸甘油酯和氯化钙联合治疗并未使平均存活时间延长至超过166分钟。