Weh H J, von Paleske A, Hossfeld D K
Cancer Genet Cytogenet. 1983 Nov;10(3):237-40. doi: 10.1016/0165-4608(83)90051-1.
A case of M4-AML (acute monoblastic leukemia) is presented which was found to be hypotetraploid (79-80-? chromosomes per metaphase) with direct chromosome preparation while 24- and 48-hour cultures contained predominantly normal and some nonclonal hyperdiploid cells. This observation emphasizes the need for both direct and culture methods to disclose the true karyotype of leukemic cells.
报告了1例M4型急性单核细胞白血病（AML）病例，通过直接染色体制备发现其为亚四倍体（每个中期相有79 - 80条染色体，数目不详），而24小时和48小时培养的细胞中主要是正常细胞和一些非克隆性超二倍体细胞。这一观察结果强调了同时使用直接法和培养法来揭示白血病细胞真实核型的必要性。
