Soifer S J, Morin F C, Kaslow D C, Heymann M A
J Dev Physiol. 1983 Aug;5(4):237-50.
Prostaglandin D2 (PGD2) lowers pulmonary arterial blood pressure without changing systemic arterial blood pressure in fetal and newborn lambs but increases pulmonary arterial pressure in older animals. We investigated the effect of PGD2 on the circulation in 15 newborn lambs, some studied intermittently from 1 to 30 days of age, with induced pulmonary arterial hypertension. PGD2 was infused intravenously in doses of 1 to 25 micrograms/kg per min. During the first 3 days of life, a 5 micrograms/kg per min infusion decreased mean pulmonary arterial pressure by 33.9%, increased mean systemic arterial pressure by 11.5% and increased cardiac output by 7.3%. After 15 days of age there was a 10.7% increase in mean pulmonary arterial pressure, a 1.8% decrease in mean systemic arterial pressure and a 6.1% increase in cardiac output. Pulmonary vascular resistance decreased by 38.2% in the first 3 days of life but increased by 9.9% after 15 days of life. With this progressive pulmonary vasoconstriction, there was systemic vasodilation with advancing age. Similar age specific effects were seen with 1 and 25 micrograms/kg per min infusions. The specificity of PGD2 for the pulmonary circulation and the attenuation of its vasodilating properties during the first week of life suggests that PGD2 may be important in the regulation of pulmonary vascular resistance and pulmonary blood flow during the immediate perinatal period.
前列腺素D2（PGD2）可降低胎儿和新生羔羊的肺动脉血压，而不改变其体循环动脉血压，但会升高成年动物的肺动脉血压。我们研究了PGD2对15只新生羔羊循环系统的影响，其中一些羔羊从1日龄至30日龄间歇性接受研究，伴有诱导性肺动脉高压。以每分钟1至25微克/千克的剂量静脉输注PGD2。在出生后的前3天，每分钟输注5微克/千克可使平均肺动脉压降低33.9%，使平均体循环动脉压升高11.5%，使心输出量增加7.3%。15日龄后，平均肺动脉压升高10.7%，平均体循环动脉压降低1.8%，心输出量增加6.1%。出生后前3天肺血管阻力降低38.2%，但15日龄后升高9.9%。随着这种进行性肺血管收缩，随着年龄增长会出现体循环血管舒张。每分钟输注1微克/千克和25微克/千克时也观察到类似的年龄特异性效应。PGD2对肺循环的特异性及其在出生后第一周血管舒张特性的减弱表明，PGD2在围产期即刻对肺血管阻力和肺血流量的调节中可能很重要。
