Morse H G, Odom L F, Tubergen D, Hays T, Blake M, Robinson A
Med Pediatr Oncol. 1983;11(5):310-8. doi: 10.1002/mpo.2950110503.
Fifty-one children with acute lymphoblastic leukemia on a common protocol of treatment were classified according to presence or absence of chromosomal abnormalities found at the time of diagnosis in bone marrow and/or blood. Twenty-two or 43% had normal karyotypes while 29 (57%) had clonal abnormalities using the Giemsa-trypsin banding technique. Thirteen of the 29 (45%) chromosomally abnormal patients relapsed while only three of 21 (14%) with normal karyotypes have relapsed with a median follow-up of 49.5 months (42-76 months). (One child with a normal karyotype did not respond to therapy.) Several hypotheses have been offered to attempt to explain the significantly better prognosis of patients with no observable initial chromosomal aberrations.
按照一种常用治疗方案接受治疗的51名急性淋巴细胞白血病患儿，根据诊断时在骨髓和/或血液中发现的染色体异常情况进行了分类。22名（43%）患儿核型正常，而采用吉姆萨 - 胰蛋白酶显带技术检测发现，29名（57%）患儿存在克隆性异常。29名染色体异常患者中有13名（45%）复发，而核型正常的21名患者中只有3名（14%）复发，中位随访时间为49.5个月（42 - 76个月）。（一名核型正常的患儿对治疗无反应。）人们提出了几种假设，试图解释初始未观察到染色体畸变的患者预后明显更好的原因。
