Waghray M, Rowley J D, Reddy P P, Reddy S V
Cancer Genet Cytogenet. 1986 Nov;23(3):225-37. doi: 10.1016/0165-4608(86)90182-2.
We studied 25 children in India with acute lymphoblastic leukemia; all of them were less than 15 years old. The karyotypes, determined with banding techniques, were correlated with clinical data. Thirteen of these patients had an adequate chromosome analysis and two others were in remission when samples were obtained. For the remaining ten, specimens were inadequate for cytogenetic analysis. Thirty-one percent of the 13 patients had a normal karyotype. The most common abnormal pattern was a hyperdiploid karyotype with greater than 50 chromosomes observed in 38% of the patients. Two patients had a Ph chromosome. Other chromosome changes, such as t(8;14), del(6), t(4;11), or t(1;19), were not seen in our series. A correlation between the karyotype and response rate and survival time was noted. Patients with a normal karyotype had a good prognosis, whereas, hyperdiploidy (greater than 50 chromosomes) and a low white blood cell count were associated with poor prognoses. Trisomy for the long arm of chromosome #1 (bands 1q25 to 1q32), which was seen in most of our patients with hyperdiploidy, also indicated a poor prognosis. Of the 25 patients, eight were from agricultural areas where they were often exposed to pesticides; there was no correlation between a history of such exposure and the karyotype of the leukemic cells.
我们研究了印度的25名急性淋巴细胞白血病患儿；他们均未满15岁。采用显带技术确定的核型与临床数据相关。其中13例患者进行了充分的染色体分析，另外2例在获取样本时处于缓解期。其余10例的标本不适合进行细胞遗传学分析。13例患者中有31%核型正常。最常见的异常模式是超二倍体核型，50条以上染色体，在38%的患者中观察到。2例患者有费城染色体。我们的系列研究中未发现其他染色体改变，如t(8;14)、del(6)、t(4;11)或t(1;19)。注意到核型与缓解率和生存时间之间存在相关性。核型正常的患者预后良好，而超二倍体（50条以上染色体）和低白细胞计数与预后不良相关。在我们大多数超二倍体患者中观察到的1号染色体长臂三体（1q25至1q32带）也提示预后不良。25例患者中，8例来自经常接触农药的农业地区；这种接触史与白血病细胞的核型之间没有相关性。
