糖皮质激素诱导的选定大鼠颌部和后肢肌肉不同纤维类型的萎缩

Glucocorticoid-induced atrophy in different fibre types of selected rat jaw and hind-limb muscles.

作者信息

Roy R R, Gardiner P F, Simpson D R, Edgerton V R

出版信息

Arch Oral Biol. 1983;28(7):639-43. doi: 10.1016/0003-9969(83)90012-2.

Abstract

Six weeks of glucocorticoid treatment (triamcinolone-acetonide-21-phosphate, 1 mg/kg of body weight daily) resulted in a similar pattern of fibre type atrophy in jaw and hind-limb muscles. Fast-twitch glycolytic fibres were significantly atrophied in all muscles investigated. Fast-twitch oxidative glycolytic fibres were affected only in the fast (white) regions of the mixed muscles, while slow-twitch oxidative fibres were unaffected. The results from pair-fed controls (food intake matched to the glucocorticoid-treated animals) showed that the glucocorticoid produced an atrophic response in addition to that produced by the decreased food intake in the experimental animals. These results suggest that the jaw musculature shares the wasting effects induced by elevated circulating glucocorticoid levels often found in stress situations.

摘要

六周的糖皮质激素治疗（曲安奈德-21-磷酸酯，每日1毫克/千克体重）导致颌部和后肢肌肉出现类似的纤维类型萎缩模式。在所有研究的肌肉中，快肌糖酵解纤维显著萎缩。快肌氧化糖酵解纤维仅在混合肌肉的快速（白色）区域受到影响，而慢肌氧化纤维未受影响。配对喂养对照组（食物摄入量与糖皮质激素治疗动物匹配）的结果表明，除了实验动物食物摄入量减少所产生的萎缩反应外，糖皮质激素还产生了萎缩反应。这些结果表明，颌部肌肉组织也会受到应激情况下常见的循环糖皮质激素水平升高所诱导的消瘦影响。