人类牙髓胶原蛋白可还原交联的年龄相关变化。

Age-related changes in reducible crosslinks of human dental pulp collagen.

作者信息

Nielsen C J, Bentley J P, Marshall F J

出版信息

Arch Oral Biol. 1983;28(8):759-64. doi: 10.1016/0003-9969(83)90112-7.

Abstract

Coronal pulp of human third molars from patients ranging in age from 16 to 40 yr was analysed for collagen, protein, calcium and reducible crosslink content. Dihydroxylsinonorleucine (DHLNL) was the major crosslink; it decreased with age. Hydroxylsinonorleucine (HLNL) and lysinonorleucine (LNL) appeared in insignificant amounts. Calcium content increased with age. Based on the premise that collagen synthesis is characterized by the presence of reducible crosslinks, the study showed that coronal pulp collagen synthesis decreases with age; this is accompanied by a decrease in collagen concentration in terms of dry weight and total protein between 16 and 30 hr of age.

摘要

对年龄在16至40岁患者的人类第三磨牙的冠髓进行了胶原蛋白、蛋白质、钙和可还原交联物含量分析。二羟基新诺赖氨酸（DHLNL）是主要的交联物；其含量随年龄增长而降低。羟基新诺赖氨酸（HLNL）和赖氨酰新诺赖氨酸（LNL）含量极少。钙含量随年龄增长而增加。基于胶原蛋白合成以可还原交联物的存在为特征这一前提，该研究表明冠髓胶原蛋白合成随年龄增长而减少；这伴随着16至30岁之间干重和总蛋白方面胶原蛋白浓度的降低。